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| カタログ番号 | HP412014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human IGF2BP1 Polyclonal Antibody (HP412014) is a rabbit polyclonal antibody detecting IGF2BP1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Danio rerio, and Chicken.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human IGF2BP1 (Val194-Asn369). | ||||||||
| ターゲット | VICKZ family member 1, Zipcode-binding protein 1, IGF2BP1, VICKZ1, Coding region determinant-binding protein, IMP1, IMP-1, ZBP1, IGF-II mRNA-binding protein 1, CRDBP, Insulin-like growth factor 2 mRNA-binding protein 1, ZBP-1, CRD-BP, IGF2 mRNA-binding protein 1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9NZI8 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is a ~63 kDa protein. RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons. 1. Huang, H. et al. (2018) Nature cell biology 20, 285-295. PMID: 29476152 2. Zhu, S. et al. (2020) Nature communications 11, 1685. PMID: 32245947 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-IGF2BP1 polyclonal antibody at 1μg/ml on various samples.
Lane 1: K562 cell lysate
Lane 2: 293T cell lysate
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