中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HT056014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human IKBKB Polyclonal Antibody (HT056014) is a rabbit polyclonal antibody detecting IKBKB in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.
Highlights
|
||||||||
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human IKBKB (Glu16-Gly345). | ||||||||
| ターゲット | IKKB, IKK-beta, Serine/threonine protein kinase IKBKB, I-kappa-B-kinase beta, Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B kinase 2, IKBKB, IKK-B, NFKBIKB, IKK2, Nuclear factor NF-kappa-B inhibitor kinase beta, IkBKB | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O14920 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) is a ~86 kDa protein. Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. 1. Cui, J. et al. (2010) Cell 141, 483-96. PMID: 20434986 2. Tsuchiya, Y. et al. (2010) Molecular cell 39, 570-82. PMID: 20797629 3. Clark, K. et al. (2011) The Biochemical journal 434, 93-104. PMID: 21138416 4. Cardinez, C. et al. (2018) The Journal of experimental medicine 215, 2715-2724. PMID: 30337470 5. Mercurio, F. et al. (1997) Science (New York, N.Y.) 278, 860-6. PMID: 9346484 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-IKBKB polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse brain lysate
Lane 2: Rat brain lysate
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
