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| カタログ番号 | HA521014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human IKBKG Polyclonal Antibody (HA521014) is a rabbit polyclonal antibody detecting IKBKG in ELISA, IHC, WB. Suitable for Rattus norvegicus, Mus musculus, Sus scrofa, and Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human IKBKG (Met1-Glu223). | ||||||||
| ターゲット | IKBKG | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9Y6K9 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 別名 | NF-kappa-B essential modulator, NEMO, FIP-3, IkB kinase-associated protein 1, IKKAP1, Inhibitor of nuclear factor kappa-B kinase subunit gamma, I-kappa-B kinase subunit gamma, IKK-gamma, IKKG, IkB kinase subunit gamma, NF-kappa-B essential modifier, IKBKG, FIP3, NEMO | ||||||||
| 背景 | NF-kappa-B essential modulator (IKBKG) is a ~48 kDa protein. Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways. Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. 1. Zhou, H. et al. (2004) Nature 427, 167-71. PMID: 14695475 2. Arimoto, K. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 15856-61. PMID: 20724660 3. Zotti, T. et al. (2011) The Journal of biological chemistry 286, 22924-33. PMID: 21518757 4. Rothwarf, DM. et al. (1998) Nature 395, 297-300. PMID: 9751060 5. Wu, CJ. et al. (2006) Nature cell biology 8, 398-406. PMID: 16547522 6. Wu, CJ. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 3023-8. PMID: 18287044 7. Cordier, F. et al. (2009) The Journal of biological chemistry 284, 2902-2907. PMID: 19033441 8. Lo, YC. et al. (2009) Molecular cell 33, 602-15. PMID: 19185524 9. Nanda, SK. et al. (2011) The Journal of experimental medicine 208, 1215-28. PMID: 21606507 10. Yang, YK. et al. (2016) The Journal of biological chemistry 291, 25921-25936. PMID: 27777308 | ||||||||
| 注意事項 | For research use only. |
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