Anti-Human IL12A/IL-12 p35/NKSF1 Recombinant Antibody (SAA0380), APC (HB936137)

Name: Anti-Human IL12A/IL-12 p35/NKSF1 Recombinant Antibody (SAA0380), APC
Brand: abinScience
SKU: HB936137
Price: 256 USD
Availability: InStock

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Numéro de catalogue	HB936137
Reactivité des espèces	Human
Applications	ELISA, FCM
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG2a, kappa
ID de clone	SAA0380
Conjugaison	APC
Cible	IL-12A, NK cell stimulatory factor chain 1, IL12A, CLMF p35, Interleukin-12 subunit alpha, IL-12 subunit p35, NKSF1, Cytotoxic lymphocyte maturation factor 35 kDa subunit
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), APC
Numéro d'accès	P29459
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Interleukin-12 subunit alpha (IL12A/IL-12 p35) is a ~24 kDa protein. Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. 1. Heufler, C. et al. (1996) European journal of immunology 26, 659-68. PMID: 8605935 2. Presky, DH. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 14002-7. PMID: 8943050 3. Wolf, SF. et al. (1991) Journal of immunology (Baltimore, Md. : 1950) 146, 3074-81. PMID: 1673147 4. Gubler, U. et al. (1991) Proceedings of the National Academy of Sciences of the United States of America 88, 4143-7. PMID: 1674604 5. Bacon, CM. et al. (1995) The Journal of experimental medicine 181, 399-404. PMID: 7528775 6. Bacon, CM. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 7307-11. PMID: 7638186 7. Collison, LW. et al. (2012) Nature immunology 13, 290-9. PMID: 22306691
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human IL12A/IL-12 p35/NKSF1 Recombinant Antibody (SAA0380), APC.pdf

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