中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HB936107 |
|---|---|
| 種反応性 | Human |
| アプリケーション | ELISA, FCM |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG2a, kappa |
| クローンID | SAA0380 |
| ターゲット | IL-12A, NK cell stimulatory factor chain 1, IL12A, CLMF p35, Interleukin-12 subunit alpha, IL-12 subunit p35, NKSF1, Cytotoxic lymphocyte maturation factor 35 kDa subunit |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P29459 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS, pH 7.4, 0.09% Sodium azide. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 背景 | Interleukin-12 subunit alpha (IL12A/IL-12 p35) is a ~24 kDa protein. Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. 1. Heufler, C. et al. (1996) European journal of immunology 26, 659-68. PMID: 8605935 2. Presky, DH. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 14002-7. PMID: 8943050 3. Wolf, SF. et al. (1991) Journal of immunology (Baltimore, Md. : 1950) 146, 3074-81. PMID: 1673147 4. Gubler, U. et al. (1991) Proceedings of the National Academy of Sciences of the United States of America 88, 4143-7. PMID: 1674604 5. Bacon, CM. et al. (1995) The Journal of experimental medicine 181, 399-404. PMID: 7528775 6. Bacon, CM. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 7307-11. PMID: 7638186 7. Collison, LW. et al. (2012) Nature immunology 13, 290-9. PMID: 22306691 |
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human IL12A/IL-12 p35/NKSF1 Antibody (SAA0380)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
