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Anti-Human IL-18 Polyclonal Antibody (HC517024)

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Vista general
Número de catálogoHC517024
Descripción
Anti-Human IL18/IL1F4 Polyclonal Antibody (HC517024) is a rabbit polyclonal antibody detecting IL1F4. Suitable for Human.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human IL18/IL1F4 (Tyr37-Asp193).
Objetivo IFN-gamma-inducing factor, IGIF, IL-1 gamma, IL-18, IL18, IL1F4, Iboctadekin, Interferon gamma-inducing factor, Interleukin-1 gamma, Interleukin-18
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso Q14116
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

Interleukin-18 (IL18/IL1F4) is a ~22 kDa protein. Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.

1. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850
2. Kato, Z. et al. (2003) Nature structural biology 10, 966-71. PMID: 14528293
3. Tsutsumi, N. et al. (2014) Nature communications 5, 5340. PMID: 25500532
4. Shi, X. et al. (2023) Nature 624, 442-450. PMID: 37993714
5. Xia, S. et al. (2021) Nature 593, 607-611. PMID: 33883744
Nota For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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