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| カタログ番号 | HV492014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human IL19 Polyclonal Antibody (HV492014) is a rabbit polyclonal antibody detecting IL19 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human IL19 (Leu25-Ala177). | ||||||||
| ターゲット | Melanoma differentiation-associated protein-like protein, Interleukin-19, IL-19, IL19, NG.1, ZMDA1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9UHD0 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Interleukin-19 (IL19) is a ~20 kDa protein. Cytokine that functions as an anti-inflammatory and proangiogenic factor. Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up-regulation of IL4 and IL13. Produced by osteocytes, stimulates granulopoiesis and neutrophil formation. Exerts its biological effect through a receptor complex consisting of a heterodimer of IL20RA and IL20RB. In turn, activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and importantly, STAT3. 1. Small, SH. et al. (2021) Science signaling 14, eaba2611. PMID: 34932373 2. Oral, HB. et al. (2006) European journal of immunology 36, 380-8. PMID: 16365913 3. Parrish-Novak, J. et al. (2002) The Journal of biological chemistry 277, 47517-23. PMID: 12351624 4. Dumoutier, L. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 167, 3545-9. PMID: 11564763 | ||||||||
| 注意事項 | For research use only. |
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