Anti-Human IL-1 alpha/IL-1F1 Recombinant Antibody (SAA0367), APC (HF802237)

Name: Anti-Human IL-1 alpha/IL-1F1 Recombinant Antibody (SAA0367), APC
Brand: abinScience
SKU: HF802237
Price: 256 USD
Availability: InStock

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Numéro de catalogue	HF802237
Reactivité des espèces	Human
Applications	ELISA, FCM
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG2a, kappa
ID de clone	SAA0367
Conjugaison	APC
Cible	IL1F1, Interleukin-1 alpha, IL1A, Hematopoietin-1, IL-1 alpha
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), APC
Numéro d'accès	P01583
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Interleukin-1 alpha (IL1A/IL1F1) is a ~30 kDa protein. Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. 1. Cohen, I. et al. (2015) Scientific reports 5, 14756. PMID: 26439902 2. Brikos, C. et al. (2007) Molecular & cellular proteomics : MCP 6, 1551-9. PMID: 17507369 3. Mosley, B. et al. (1987) The Journal of biological chemistry 262, 2941-4. PMID: 2950091 4. Wu, T. et al. (2004) Cytokine 25, 11-20. PMID: 14687581 5. Spiekstra, SW. et al. (2005) Experimental dermatology 14, 109-16. PMID: 15679580
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.