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| カタログ番号 | HY262013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA, WB | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1520 | ||||
| ターゲット | IL3, Hematopoietic growth factor, Multipotential colony-stimulating factor, IL-3, Mast cell growth factor, Interleukin-3, P-cell-stimulating factor, MCGF | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P08700 | ||||
| RRID | Anti-Human IL3 Antibody (SAA1520) (abinScience Cat# HY262013, RRID:AB_3727281) |
||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Interleukin-3 (IL3) is a ~17 kDa protein. Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Also stimulates mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. 1. Guba, SC. et al. (1989) The Journal of clinical investigation 84, 1701-6. PMID: 2556442 2. Okayama, Y. et al. (1993) Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 23, 901-10. PMID: 10779277 3. Hong, L. et al. (2020) Cytokine 136, 155268. PMID: 32889153 4. Luo, XJ. et al. (2012) PloS one 7, e50375. PMID: 23226269 5. Khapli, SM. et al. (2003) Journal of immunology (Baltimore, Md. : 1950) 171, 142-51. PMID: 12816992 6. Broughton, SE. et al. (2018) Nature communications 9, 386. PMID: 29374162 7. López, C. et al. (2017) Journal of cellular biochemistry 118, 1330-1340. PMID: 27862234 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human IL3 Antibody (SAA1520)
Detects recombinant human IL3 (Catalog No: HY262012) in indirect ELISA.
Detects recombinant human IL3 (Catalog No: HY262011) in indirect ELISA.
Western blot analysis was performed using anti-IL3 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human IL3 (Catalog No: HY262011)
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