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| カタログ番号 | HD553014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human INPPL1 Polyclonal Antibody (HD553014) is a rabbit polyclonal antibody detecting INPPL1. Suitable for Human, Rat, and Mouse.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human INPPL1 (Asp422-Thr730). | ||||||||
| ターゲット | EC:3.1.3.86, INPPL-1, INPPL1, Inositol polyphosphate phosphatase-like protein 1, Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2, Protein 51C, SH2 domain-containing inositol 5'-phosphatase 2, SH2 domain-containing inositol phosphatase 2, SHIP-2, SHIP2 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O15357 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1) is a ~138 kDa protein. Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Required for correct mitotic spindle orientation and therefore progression of mitosis. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. 1. Vandeput, F. et al. (2006) Cellular signalling 18, 2193-9. PMID: 16824732 2. Habib, T. et al. (1998) The Journal of biological chemistry 273, 18605-9. PMID: 9660833 3. Dyson, JM. et al. (2001) The Journal of cell biology 155, 1065-79. PMID: 11739414 4. Dyson, JM. et al. (2003) Blood 102, 940-8. PMID: 12676785 5. Prasad, NK. et al. (2005) The Journal of biological chemistry 280, 13129-36. PMID: 15668240 6. Hasegawa, J. et al. (2011) The Journal of cell biology 193, 901-16. PMID: 21624956 7. Prasad, N. et al. (2002) Journal of cell science 115, 3807-15. PMID: 12235291 8. Koch, A. et al. (2005) Oncogene 24, 3436-47. PMID: 15735664 9. Zhuang, G. et al. (2007) The Journal of biological chemistry 282, 2683-94. PMID: 17135240 10. Pengal, RA. et al. (2003) The Journal of biological chemistry 278, 22657-63. PMID: 12690104 | ||||||||
| 注意事項 | For research use only |
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