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| カタログ番号 | HC458014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human IRF3 Polyclonal Antibody (HC458014) is a rabbit polyclonal antibody detecting IRF3 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human IRF3 (Met1-Ser123). | ||||||||
| ターゲット | IRF-3, IRF3, Interferon regulatory factor 3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q14653 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Interferon regulatory factor 3 (IRF3) is a ~47 kDa protein. Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. 1. Tanaka, Y. et al. (2012) Science signaling 5, ra20. PMID: 22394562 2. Wang, S. et al. (2013) Journal of virology 87, 12814-27. PMID: 24049179 3. Liu, S. et al. (2015) Science (New York, N.Y.) 347, aaa2630. PMID: 25636800 4. Zhao, B. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, E3403-12. PMID: 27302953 5. Li, D. et al. (2019) Journal of cell science 133. PMID: 31340999 6. Yang, S. et al. (2023) Molecular cell 83, 298-313.e8. PMID: 36603579 7. Au, WC. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 11657-61. PMID: 8524823 8. Zhu, H. et al. (2024) Cell death & disease 15, 727. PMID: 39362857 9. Yoneyama, M. et al. (2002) Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 22, 73-6. PMID: 11846977 10. Solis, M. et al. (2006) Biochemical pharmacology 72, 1469-76. PMID: 16846591 | ||||||||
| 注意事項 | For research use only. |
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