

| Número de catálogo | HX152014 | ||||||||
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| Descripción |
Anti-Human IST1 Polyclonal Antibody (HX152014) is a rabbit polyclonal antibody detecting IST1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pongo abelii.
Highlights
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| Reactividad de especies | Human, Mouse, Rat | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human IST1 (Met1-Glu186). | ||||||||
| Objetivo | Putative MAPK-activating protein PM28, IST1, IST1 homolog, KIAA0174, hIST1 | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | P53990 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | IST1 homolog is a ~39 kDa protein. ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation. Is required for efficient abscission during cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2. 1. Bajorek, M. et al. (2009) Molecular biology of the cell 20, 1360-73. PMID: 19129479 2. Vietri, M. et al. (2015) Nature 522, 231-5. PMID: 26040712 3. Gu, M. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E2166-E2175. PMID: 28242692 4. Agromayor, M. et al. (2009) Molecular biology of the cell 20, 1374-87. PMID: 19129480 5. Allison, R. et al. (2013) The Journal of cell biology 202, 527-43. PMID: 23897888 | ||||||||
| Nota | For research use only. |
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