Anti-Human KANK2 Polyclonal Antibody (HA852014)

Name: Anti-Human KANK2 Polyclonal Antibody
Brand: abinScience
SKU: HA852014
Price: 96 USD
Availability: InStock

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Número de catálogo

HA852014

Descripción

Anti-Human KANK2 Polyclonal Antibody (HA852014) is a rabbit polyclonal antibody detecting KANK2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human KANK2 (Ser591-Glu851).

Objetivo

Ankyrin repeat domain-containing protein 25, SRC-interacting protein, SRC-1-interacting protein, SRC1-interacting protein, ANKRD25, KIAA1518, MXRA3, KN motif and ankyrin repeat domain-containing protein 2, Matrix-remodeling-associated protein 3, KANK2, SIP

Purificación

Purified by antigen affinity column.

Número de acceso

Q63ZY3

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

KN motif and ankyrin repeat domain-containing protein 2 (KANK2) is a ~91 kDa protein. Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3. Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria. Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis. Involved in the negative control of vitamin D receptor signaling pathway. Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway.

1. Zhang, Y. et al. (2007) The EMBO journal 26, 2645-57. PMID: 17476305

2. Wang, D. et al. (2012) The Journal of biological chemistry 287, 12612-21. PMID: 22371500

3. Ramot, Y. et al. (2014) Journal of medical genetics 51, 388-94. PMID: 24671081

4. Zhu, Y. et al. (2008) Biochimica et biophysica acta 1780, 128-33. PMID: 17996375

5. Gee, HY. et al. (2015) The Journal of clinical investigation 125, 2375-84. PMID: 25961457

Nota

For research use only.

Imágenes

Western blot

Western blot analysis was performed using anti-CDC5L polyclonal antibody at 1ug/mL on various samples.
Lane 1: HepG2 cell lysate
Lane 2: Jurkat cell lysate
Lane 3: Mouse testis lysate
Lane 4: Rat testis lysate

Referencias

Datasheet

Anti-Human KANK2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Human KANK2 Polyclonal Antibody (HA852014)

Vista general

Imágenes

Referencias

Datasheet

SDS