Anti-Human KANK2 Polyclonal Antibody (HA852014)

Name: Anti-Human KANK2 Polyclonal Antibody
Brand: abinScience
SKU: HA852014
Price: 96 USD
Availability: InStock

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Fiche technique
SDS

Aperçu

Numéro de catalogue

HA852014

Description

Anti-Human KANK2 Polyclonal Antibody (HA852014) is a rabbit polyclonal antibody detecting KANK2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human KANK2 (Ser591-Glu851).

Cible

Ankyrin repeat domain-containing protein 25, SRC-interacting protein, SRC-1-interacting protein, SRC1-interacting protein, ANKRD25, KIAA1518, MXRA3, KN motif and ankyrin repeat domain-containing protein 2, Matrix-remodeling-associated protein 3, KANK2, SIP

Purification

Purified by antigen affinity column.

Numéro d'accès

Q63ZY3

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

KN motif and ankyrin repeat domain-containing protein 2 (KANK2) is a ~91 kDa protein. Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3. Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria. Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis. Involved in the negative control of vitamin D receptor signaling pathway. Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway.

1. Zhang, Y. et al. (2007) The EMBO journal 26, 2645-57. PMID: 17476305

2. Wang, D. et al. (2012) The Journal of biological chemistry 287, 12612-21. PMID: 22371500

3. Ramot, Y. et al. (2014) Journal of medical genetics 51, 388-94. PMID: 24671081

4. Zhu, Y. et al. (2008) Biochimica et biophysica acta 1780, 128-33. PMID: 17996375

5. Gee, HY. et al. (2015) The Journal of clinical investigation 125, 2375-84. PMID: 25961457

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-CDC5L polyclonal antibody at 1ug/mL on various samples.
Lane 1: HepG2 cell lysate
Lane 2: Jurkat cell lysate
Lane 3: Mouse testis lysate
Lane 4: Rat testis lysate

Reférences

Fiche technique

Anti-Human KANK2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human KANK2 Polyclonal Antibody (HA852014)

Aperçu

Images

Reférences

Fiche technique

SDS