Anti-Human KCNH1/EAG1 Recombinant Antibody (SAA1808) (HF003013)

Name: Anti-Human KCNH1/EAG1 Recombinant Antibody (SAA1808)
Brand: abinScience
SKU: HF003013
Price: 196 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HF003013

Reactividad de especies

Human

Aplicaciones

ELISA

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG2a, kappa

ID de clon

SAA1808

Objetivo

EAG channel 1, KCNH1, Voltage-gated potassium channel subunit Kv10.1, h-eag, hEAG1, Ether-a-go-go potassium channel 1, EAG, EAG1, Potassium voltage-gated channel subfamily H member 1

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

O95259

RRID

Anti-Human KCNH1/EAG1 Antibody (SAA1808) (abinScience Cat# HF003013, RRID:AB_3727570)

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Fondo

Voltage-gated delayed rectifier potassium channel KCNH1 (EAG1) is a ~111 kDa protein. Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate. The activation kinetics depend on the prepulse potential and external divalent cation concentration. With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation. The time course of activation is biphasic with a fast and a slowly activating current component. Activates at more positive membrane potentials and exhibit a steeper activation curve.

1. Schönherr, R. et al. (2000) The EMBO journal 19, 3263-71. PMID: 10880439

2. Schönherr, R. et al. (2002) FEBS letters 514, 204-8. PMID: 11943152

3. Marques-Carvalho, MJ. et al. (2012) Journal of molecular biology 423, 34-46. PMID: 22732247

4. Simons, C. et al. (2015) Nature genetics 47, 73-7. PMID: 25420144

5. Mortensen, LS. et al. (2015) The Journal of physiology 593, 181-96. PMID: 25556795

6. Kortüm, F. et al. (2015) Nature genetics 47, 661-7. PMID: 25915598

7. Han, B. et al. (2016) Scientific reports 6, 23417. PMID: 27005320

8. Lörinczi, E. et al. (2016) The Journal of biological chemistry 291, 17907-18. PMID: 27325704

9. Marques-Carvalho, MJ. et al. (2016) Structure (London, England : 1993) 24, 1742-1754. PMID: 27618660

10. Ma, L. et al. (2018) Biochemical pharmacology 158, 60-72. PMID: 30149017

Nota

For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human KCNH1/EAG1 Antibody (SAA1808)

Referencias

Datasheet

Anti-Human KCNH1/EAG1 Recombinant Antibody (SAA1808).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo