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| カタログ番号 | HF003013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1808 | ||||
| ターゲット | EAG channel 1, KCNH1, Voltage-gated potassium channel subunit Kv10.1, h-eag, hEAG1, Ether-a-go-go potassium channel 1, EAG, EAG1, Potassium voltage-gated channel subfamily H member 1 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | O95259 | ||||
| RRID | Anti-Human KCNH1/EAG1 Antibody (SAA1808) (abinScience Cat# HF003013, RRID:AB_3727570) |
||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Voltage-gated delayed rectifier potassium channel KCNH1 (EAG1) is a ~111 kDa protein. Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate. The activation kinetics depend on the prepulse potential and external divalent cation concentration. With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation. The time course of activation is biphasic with a fast and a slowly activating current component. Activates at more positive membrane potentials and exhibit a steeper activation curve. 1. Schönherr, R. et al. (2000) The EMBO journal 19, 3263-71. PMID: 10880439 2. Schönherr, R. et al. (2002) FEBS letters 514, 204-8. PMID: 11943152 3. Marques-Carvalho, MJ. et al. (2012) Journal of molecular biology 423, 34-46. PMID: 22732247 4. Simons, C. et al. (2015) Nature genetics 47, 73-7. PMID: 25420144 5. Mortensen, LS. et al. (2015) The Journal of physiology 593, 181-96. PMID: 25556795 6. Kortüm, F. et al. (2015) Nature genetics 47, 661-7. PMID: 25915598 7. Han, B. et al. (2016) Scientific reports 6, 23417. PMID: 27005320 8. Lörinczi, E. et al. (2016) The Journal of biological chemistry 291, 17907-18. PMID: 27325704 9. Marques-Carvalho, MJ. et al. (2016) Structure (London, England : 1993) 24, 1742-1754. PMID: 27618660 10. Ma, L. et al. (2018) Biochemical pharmacology 158, 60-72. PMID: 30149017 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human KCNH1/EAG1 Antibody (SAA1808)
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