Anti-Human KCNH1/EAG1 Recombinant Antibody (SAA1808) (HF003013)

Name: Anti-Human KCNH1/EAG1 Recombinant Antibody (SAA1808)
Brand: abinScience
SKU: HF003013
Price: 196 USD
Availability: InStock

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Цена(USD):

Спецификация:

50ug
100ug
1mg

Количество:

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Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер

HF003013

Реактивность видов

Human

Применения

ELISA

Хозяинский вид

Mouse

Клоональность

Monoclonal

Изотип

IgG2a, kappa

ID клона

SAA1808

Цель

EAG channel 1, KCNH1, Voltage-gated potassium channel subunit Kv10.1, h-eag, hEAG1, Ether-a-go-go potassium channel 1, EAG, EAG1, Potassium voltage-gated channel subfamily H member 1

Уровень эндотоксинов

Please contact with the lab for this information.

Чистота

>95% as determined by SDS-PAGE.

Очистка

Protein A/G purified from cell culture supernatant.

Номер доступа

O95259

RRID

Anti-Human KCNH1/EAG1 Antibody (SAA1808) (abinScience Cat# HF003013, RRID:AB_3727570)

Форма

Liquid

Буфер хранения

0.01M PBS pH 7.4

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:2000-1:20000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Фон

Voltage-gated delayed rectifier potassium channel KCNH1 (EAG1) is a ~111 kDa protein. Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate. The activation kinetics depend on the prepulse potential and external divalent cation concentration. With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation. The time course of activation is biphasic with a fast and a slowly activating current component. Activates at more positive membrane potentials and exhibit a steeper activation curve.

1. Schönherr, R. et al. (2000) The EMBO journal 19, 3263-71. PMID: 10880439

2. Schönherr, R. et al. (2002) FEBS letters 514, 204-8. PMID: 11943152

3. Marques-Carvalho, MJ. et al. (2012) Journal of molecular biology 423, 34-46. PMID: 22732247

4. Simons, C. et al. (2015) Nature genetics 47, 73-7. PMID: 25420144

5. Mortensen, LS. et al. (2015) The Journal of physiology 593, 181-96. PMID: 25556795

6. Kortüm, F. et al. (2015) Nature genetics 47, 661-7. PMID: 25915598

7. Han, B. et al. (2016) Scientific reports 6, 23417. PMID: 27005320

8. Lörinczi, E. et al. (2016) The Journal of biological chemistry 291, 17907-18. PMID: 27325704

9. Marques-Carvalho, MJ. et al. (2016) Structure (London, England : 1993) 24, 1742-1754. PMID: 27618660

10. Ma, L. et al. (2018) Biochemical pharmacology 158, 60-72. PMID: 30149017

Примечание

For research use only.

Изображения

SDS-PAGE

SDS-PAGE for Anti-Human KCNH1/EAG1 Antibody (SAA1808)

Ссылки

Даташит

Anti-Human KCNH1/EAG1 Recombinant Antibody (SAA1808).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа