Anti-Human KCNH2/ERG1 Polyclonal Antibody (HC535014)

Name: Anti-Human KCNH2/ERG1 Polyclonal Antibody
Brand: abinScience
SKU: HC535014
Price: 96 USD
Availability: InStock

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Especificación:

20ug
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Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HC535014

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human KCNH2/ERG1 (Pro10-Lys135).

Objetivo

H-ERG, ERG, HERG, hERG1, hERG-1, Potassium voltage-gated channel subfamily H member 2, ERG-1, KCNH2, Eag homolog, ERG1, Eag-related protein 1, Ether-a-go-go-related gene potassium channel 1, Voltage-gated potassium channel subunit Kv11.1, Ether-a-go-go-related protein 1

Purificación

Purified by antigen affinity column.

Número de acceso

Q12809

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Voltage-gated inwardly rectifying potassium channel KCNH2 (ERG1) is a ~126 kDa protein. Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization. Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity.

1. Abbott, GW. et al. (1999) Cell 97, 175-87. PMID: 10219239

2. Kagan, A. et al. (2000) The Journal of biological chemistry 275, 11241-8. PMID: 10753933

3. Paulussen, A. et al. (2000) Human mutation 15, 483. PMID: 10790218

4. Cui, J. et al. (2000) Current biology : CB 10, 671-4. PMID: 10837251

5. Yang, P. et al. (2002) Circulation 105, 1943-8. PMID: 11997281

6. Gong, Q. et al. (2002) American journal of physiology. Heart and circulatory physiology 283, H77-84. PMID: 12063277

7. Guasti, L. et al. (2008) Molecular and cellular biology 28, 5043-60. PMID: 18559421

8. Aidery, P. et al. (2012) Biochemical and biophysical research communications 418, 830-5. PMID: 22314138

9. Ng, CA. et al. (2012) PloS one 7, e31640. PMID: 22359612

10. Kang, Y. et al. (2015) The Biochemical journal 472, 71-82. PMID: 26363003

Nota

For research use only.

Imágenes

Western blot

Western blot analysis was performed using anti-KCNH2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Jurkat cell lysate
Lane 2: 293T cell lysate