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Anti-Human KCNK2 Polyclonal Antibody (HF823014)

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Aperçu
Numéro de catalogueHF823014
Description
Anti-Human KCNK2 Polyclonal Antibody (HF823014) is a rabbit polyclonal antibody detecting KCNK2 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human KCNK2 (Asp309-Lys426).
Cible Potassium channel subfamily K member 2, Outward rectifying potassium channel protein TREK-1, TREK-1 K(+) channel subunit, Two pore domain potassium channel TREK-1, Two pore potassium channel TPKC1, KCNK2, TREK, TREK1
Purification Purified by antigen affinity column.
Numéro d'accès O95069
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Potassium channel subfamily K member 2 (KCNK2) is a ~47 kDa protein. K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, acidic pH, heat and lipids. Reversibly converts between a voltage-insensitive K(+) 'leak' channel and a voltage-dependent outward rectifying K(+) channel in a phosphorylation-dependent manner. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties.

1. Patel, AJ. et al. (1999) Nature neuroscience 2, 422-6. PMID: 10321245
2. Meadows, HJ. et al. (2000) Pflugers Archiv : European journal of physiology 439, 714-22. PMID: 10784345
3. Bockenhauer, D. et al. (2001) Nature neuroscience 4, 486-91. PMID: 11319556
4. Plant, LD. et al. (2012) Science signaling 5, ra84. PMID: 23169818
5. Royal, P. et al. (2019) Neuron 101, 232-245.e6. PMID: 30573346
6. Sorum, B. et al. (2024) Nature communications 15, 3142. PMID: 38605031
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Human KCNK2 Polyclonal Antibody

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