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| カタログ番号 | HF823014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human KCNK2 Polyclonal Antibody (HF823014) is a rabbit polyclonal antibody detecting KCNK2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human KCNK2 (Asp309-Lys426). | ||||||||
| ターゲット | Potassium channel subfamily K member 2, Outward rectifying potassium channel protein TREK-1, TREK-1 K(+) channel subunit, Two pore domain potassium channel TREK-1, Two pore potassium channel TPKC1, KCNK2, TREK, TREK1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O95069 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Potassium channel subfamily K member 2 (KCNK2) is a ~47 kDa protein. K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, acidic pH, heat and lipids. Reversibly converts between a voltage-insensitive K(+) 'leak' channel and a voltage-dependent outward rectifying K(+) channel in a phosphorylation-dependent manner. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. 1. Patel, AJ. et al. (1999) Nature neuroscience 2, 422-6. PMID: 10321245 2. Meadows, HJ. et al. (2000) Pflugers Archiv : European journal of physiology 439, 714-22. PMID: 10784345 3. Bockenhauer, D. et al. (2001) Nature neuroscience 4, 486-91. PMID: 11319556 4. Plant, LD. et al. (2012) Science signaling 5, ra84. PMID: 23169818 5. Royal, P. et al. (2019) Neuron 101, 232-245.e6. PMID: 30573346 6. Sorum, B. et al. (2024) Nature communications 15, 3142. PMID: 38605031 | ||||||||
| 注意事項 | For research use only. |
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