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Anti-Human KCNK3 Polyclonal Antibody (HT022014)

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Vista general
Número de catálogoHT022014
Descripción
Anti-Human KCNK3 Polyclonal Antibody (HT022014) is a rabbit polyclonal antibody detecting KCNK3. Suitable for Human.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human KCNK3 (Leu244-Val394).
Objetivo Acid-sensitive potassium channel protein TASK-1, KCNK3, Potassium channel subfamily K member 3, TASK, TASK1, TWIK-related acid-sensitive K(+) channel 1, Two pore K(+) channel KT3.1, Two pore potassium channel KT3.1
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso O14649
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

Potassium channel subfamily K member 3 (KCNK3) is a ~43 kDa protein. K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Changes ion selectivity and becomes permeable to Na(+) ions in response to extracellular acidification. Protonation of the pH sensor His-98 stabilizes C-type inactivation conformation likely converting the channel from outward K(+)-conducting, to inward Na(+)-conducting to nonconductive state. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties.

1. Plant, LD. et al. (2012) Science signaling 5, ra84. PMID: 23169818
2. Schewe, M. et al. (2016) Cell 164, 937-49. PMID: 26919430
3. Rödström, KEJ. et al. (2020) Nature 582, 443-447. PMID: 32499642
4. Sörmann, J. et al. (2022) Nature genetics 54, 1534-1543. PMID: 36195757
5. Duprat, F. et al. (1997) The EMBO journal 16, 5464-71. PMID: 9312005
6. Ma, L. et al. (2012) The Journal of biological chemistry 287, 37145-53. PMID: 22948150
Nota For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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