

| Numéro de catalogue | HT022014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human KCNK3 Polyclonal Antibody (HT022014) is a rabbit polyclonal antibody detecting KCNK3. Suitable for Human.
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human KCNK3 (Leu244-Val394). | ||||||||
| Cible | Acid-sensitive potassium channel protein TASK-1, KCNK3, Potassium channel subfamily K member 3, TASK, TASK1, TWIK-related acid-sensitive K(+) channel 1, Two pore K(+) channel KT3.1, Two pore potassium channel KT3.1 | ||||||||
| Niveau d'endotoxines | Please contact with the lab for this information. | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | O14649 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Contexte | Potassium channel subfamily K member 3 (KCNK3) is a ~43 kDa protein. K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Changes ion selectivity and becomes permeable to Na(+) ions in response to extracellular acidification. Protonation of the pH sensor His-98 stabilizes C-type inactivation conformation likely converting the channel from outward K(+)-conducting, to inward Na(+)-conducting to nonconductive state. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. 1. Plant, LD. et al. (2012) Science signaling 5, ra84. PMID: 23169818 2. Schewe, M. et al. (2016) Cell 164, 937-49. PMID: 26919430 3. Rödström, KEJ. et al. (2020) Nature 582, 443-447. PMID: 32499642 4. Sörmann, J. et al. (2022) Nature genetics 54, 1534-1543. PMID: 36195757 5. Duprat, F. et al. (1997) The EMBO journal 16, 5464-71. PMID: 9312005 6. Ma, L. et al. (2012) The Journal of biological chemistry 287, 37145-53. PMID: 22948150 | ||||||||
| Note | For research use only |
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