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| カタログ番号 | HT022014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human KCNK3 Polyclonal Antibody (HT022014) is a rabbit polyclonal antibody detecting KCNK3. Suitable for Human.
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human KCNK3 (Leu244-Val394). | ||||||||
| ターゲット | Acid-sensitive potassium channel protein TASK-1, KCNK3, Potassium channel subfamily K member 3, TASK, TASK1, TWIK-related acid-sensitive K(+) channel 1, Two pore K(+) channel KT3.1, Two pore potassium channel KT3.1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O14649 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Potassium channel subfamily K member 3 (KCNK3) is a ~43 kDa protein. K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Changes ion selectivity and becomes permeable to Na(+) ions in response to extracellular acidification. Protonation of the pH sensor His-98 stabilizes C-type inactivation conformation likely converting the channel from outward K(+)-conducting, to inward Na(+)-conducting to nonconductive state. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. 1. Plant, LD. et al. (2012) Science signaling 5, ra84. PMID: 23169818 2. Schewe, M. et al. (2016) Cell 164, 937-49. PMID: 26919430 3. Rödström, KEJ. et al. (2020) Nature 582, 443-447. PMID: 32499642 4. Sörmann, J. et al. (2022) Nature genetics 54, 1534-1543. PMID: 36195757 5. Duprat, F. et al. (1997) The EMBO journal 16, 5464-71. PMID: 9312005 6. Ma, L. et al. (2012) The Journal of biological chemistry 287, 37145-53. PMID: 22948150 | ||||||||
| 注意事項 | For research use only |
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