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Anti-Human KDM1A Polyclonal Antibody (HD579014)

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Vista general
Número de catálogoHD579014
Descripción
Anti-Human KDM1A Polyclonal Antibody (HD579014) is a rabbit polyclonal antibody detecting KDM1A. Suitable for Rat, Mouse, and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human KDM1A (Arg524-Met852).
Objetivo AOF2, BHC110, BRAF35-HDAC complex protein BHC110, EC:1.14.11.-, EC:1.14.11.65, EC:1.14.99.66, Flavin-containing amine oxidase domain-containing protein 2, KDM1, KDM1A, KIAA0601, LSD1, Lysine-specific histone demethylase 1A, [histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso O60341
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

Lysine-specific histone demethylase 1A (KDM1A) is a ~92 kDa protein. Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2). May play a role in the repression of neuronal genes.

1. Shi, Y. et al. (2004) Cell 119, 941-53. PMID: 15620353
2. Forneris, F. et al. (2005) FEBS letters 579, 2203-7. PMID: 15811342
3. Lee, MG. et al. (2005) Nature 437, 432-5. PMID: 16079794
4. Metzger, E. et al. (2005) Nature 437, 436-9. PMID: 16079795
5. Shi, YJ. et al. (2005) Molecular cell 19, 857-64. PMID: 16140033
6. Forneris, F. et al. (2005) The Journal of biological chemistry 280, 41360-5. PMID: 16223729
7. Luo, H. et al. (2016) Cell reports 15, 2665-78. PMID: 27292636
10. Lin, Y. et al. (2010) The EMBO journal 29, 1803-16. PMID: 20389281
Nota For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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g/mol
Formula
C₁ × V₁ = C₂ × V₂
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human KDM1A Polyclonal Antibody

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