中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HD579014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human KDM1A Polyclonal Antibody (HD579014) is a rabbit polyclonal antibody detecting KDM1A. Suitable for Rat, Mouse, and Human.
Highlights
|
||||||||
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human KDM1A (Arg524-Met852). | ||||||||
| ターゲット | AOF2, BHC110, BRAF35-HDAC complex protein BHC110, EC:1.14.11.-, EC:1.14.11.65, EC:1.14.99.66, Flavin-containing amine oxidase domain-containing protein 2, KDM1, KDM1A, KIAA0601, LSD1, Lysine-specific histone demethylase 1A, [histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O60341 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 背景 | Lysine-specific histone demethylase 1A (KDM1A) is a ~92 kDa protein. Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2). May play a role in the repression of neuronal genes. 1. Shi, Y. et al. (2004) Cell 119, 941-53. PMID: 15620353 2. Forneris, F. et al. (2005) FEBS letters 579, 2203-7. PMID: 15811342 3. Lee, MG. et al. (2005) Nature 437, 432-5. PMID: 16079794 4. Metzger, E. et al. (2005) Nature 437, 436-9. PMID: 16079795 5. Shi, YJ. et al. (2005) Molecular cell 19, 857-64. PMID: 16140033 6. Forneris, F. et al. (2005) The Journal of biological chemistry 280, 41360-5. PMID: 16223729 7. Luo, H. et al. (2016) Cell reports 15, 2665-78. PMID: 27292636 10. Lin, Y. et al. (2010) The EMBO journal 29, 1803-16. PMID: 20389281 | ||||||||
| 注意事項 | For research use only |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
