

| Каталожный номер | HF843013 | ||||
|---|---|---|---|---|---|
| Реактивность видов | Human | ||||
| Применения | ELISA, IF, IP | ||||
| Хозяинский вид | Mouse | ||||
| Клоональность | Monoclonal | ||||
| Изотип | IgG2a, kappa | ||||
| ID клона | SAA0204 | ||||
| Цель | Lysine-specific demethylase 4A, JMJD2, Jumonji domain-containing protein 2A, KDM4A, KIAA0677, JHDM3A, [histone H3]-trimethyl-L-lysine(9) demethylase 4A, [histone H3]-trimethyl-L-lysine(36) demethylase 4A, JMJD2A, JmjC domain-containing histone demethylation protein 3A | ||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||
| Чистота | >95% as determined by SDS-PAGE. | ||||
| Очистка | Protein A/G purified from cell culture supernatant. | ||||
| Номер доступа | O75164 | ||||
| RRID | Anti-Human KDM4A IP Antibody (SAA0204) (abinScience Cat# HF843013, RRID:AB_3729738) |
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| Форма | Liquid | ||||
| Буфер хранения | 0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| Фон | Lysine-specific demethylase 4A (KDM4A/JMJD2A) is a ~120 kDa protein. Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Also able to demethylate histone H1-4 methylated at 'Lys-26' (H1.4K26me1, H1.4K26me2 and H1.4K26me3). 1. Whetstine, JR. et al. (2006) Cell 125, 467-81. PMID: 16603238 2. Bavetsias, V. et al. (2016) Journal of medicinal chemistry 59, 1388-409. PMID: 26741168 3. Tan, MK. et al. (2011) Molecular and cellular biology 31, 3687-99. PMID: 21768309 4. Trojer, P. et al. (2009) The Journal of biological chemistry 284, 8395-405. PMID: 19144645 | ||||
| Примечание | For research use only. |

SDS-PAGE for Anti-Human KDM4A IP Antibody (SAA0204)
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