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| カタログ番号 | HW795013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA, IF, IP | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG | ||||
| クローンID | SAA0206 | ||||
| ターゲット | DXS1272E, Protein Xe169, Protein SmcX, JARID1C, [histone H3]-trimethyl-L-lysine(4) demethylase 5C, XE169, SMCX, Lysine-specific demethylase 5C, KDM5C, Jumonji/ARID domain-containing protein 1C, Histone demethylase JARID1C | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P41229 | ||||
| RRID | Anti-Human KDM5C IP Antibody (SAA0206) (abinScience Cat# HW795013, RRID:AB_3729740) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Lysine-specific demethylase 5C (KDM5C) is a ~175 kDa protein. Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. 1. Tumber, A. et al. (2017) Cell chemical biology 24, 371-380. PMID: 28262558 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human KDM5C IP Antibody (SAA0206)
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