

| Каталожный номер | HD363014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human KDM7A Polyclonal Antibody (HD363014) is a rabbit polyclonal antibody detecting KDM7A. Suitable for Mouse and Human.
Highlights
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| Реактивность видов | Human, Mouse | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human KDM7A (Gln116-Asn479). | ||||||||
| Цель | EC:1.14.11.65, JHDM1D, JmjC domain-containing histone demethylation protein 1D, KDM7, KDM7A, KIAA1718, Lysine-specific demethylase 7, Lysine-specific demethylase 7A, [histone H3]-dimethyl-L-lysine9 demethylase 7A | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q6ZMT4 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Фон | Lysine-specific demethylase 7A (KDM7A) is a ~106 kDa protein. Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. 1. Horton, JR. et al. (2010) Nature structural & molecular biology 17, 38-43. PMID: 20023638 2. Qi, HH. et al. (2010) Nature 466, 503-7. PMID: 20622853 | ||||||||
| Примечание | For research use only |
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