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| カタログ番号 | HD586014 | ||||||||
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| 説明 |
Anti-Human KHDC3L Polyclonal Antibody (HD586014) is a rabbit polyclonal antibody detecting KHDC3L. Suitable for Human.
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human KHDC3L (Met1-Ser137). | ||||||||
| ターゲット | C6orf221, ECAT1, ES cell-associated transcript 1 protein, KH domain-containing protein 3, KHDC3-like protein, KHDC3L | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q587J8 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | KH domain-containing protein 3 (KHDC3L) is a ~24 kDa protein. Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development. The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos. They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation. KHDC3 ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process. Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function. 1. Zhang, W. et al. (2019) PLoS biology 17, e3000468. PMID: 31609975 | ||||||||
| 注意事項 | For research use only |
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