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| カタログ番号 | HC692014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human KHDRBS1 Polyclonal Antibody (HC692014) is a rabbit polyclonal antibody detecting KHDRBS1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human KHDRBS1 (Lys111-Gly276). | ||||||||
| ターゲット | p21 Ras GTPase-activating protein-associated p62, GAP-associated tyrosine phosphoprotein p62, KH domain-containing, RNA-binding, signal transduction-associated protein 1, SAM68, p68, Sam68, KHDRBS1, Src-associated in mitosis 68 kDa protein | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q07666 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) is a ~48 kDa protein. Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. 1. Rajanala, K. et al. (2012) PloS one 7, e29921. PMID: 22253824 2. Nakka, KK. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, E3374-83. PMID: 26080397 3. Paronetto, MP. et al. (2007) The Journal of cell biology 176, 929-39. PMID: 17371836 4. Pedrotti, S. et al. (2010) The EMBO journal 29, 1235-47. PMID: 20186123 | ||||||||
| 注意事項 | For research use only. |
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