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| カタログ番号 | HD508014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human KIDINS220 Polyclonal Antibody (HD508014) is a rabbit polyclonal antibody detecting KIDINS220. Suitable for Rat and Human.
Highlights
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| 種反応性 | Human, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human KIDINS220 (Met1-Lys168). | ||||||||
| ターゲット | ARMS, Ankyrin repeat-rich membrane-spanning protein, KIAA1250, KIDINS220, Kinase D-interacting substrate of 220 kDa | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9ULH0 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Kinase D-interacting substrate of 220 kDa (KIDINS220) is a ~196 kDa protein. Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. | ||||||||
| 注意事項 | For research use only |
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