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| カタログ番号 | HP704014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human KIF2C (Asn229-Ser589). | ||||||||
| ターゲット | Mitotic centromere-associated kinesin, Kinesin-like protein 6, KIF2C, Kinesin-like protein KIF2C, KNSL6, MCAK | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q99661 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Kinesin-like protein KIF2C is a ~81 kDa protein. In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment. 1. Tanenbaum, ME. et al. (2011) Current biology : CB 21, 1356-65. PMID: 21820309 2. Bakhoum, SF. et al. (2009) Nature cell biology 11, 27-35. PMID: 19060894 3. Shrestha, RL. et al. (2013) Current biology : CB 23, 1514-26. PMID: 23891108 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-KIF2C polyclonal antibody at 1μg/ml on various samples.
Lane 1: K562 cell lysate
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