

| Каталожный номер | HP554014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human KMT5A Polyclonal Antibody (HP554014) is a rabbit polyclonal antibody detecting KMT5A in ELISA, IHC, WB. Suitable for Bovine, Human, and Mouse.
Highlights
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| Реактивность видов | Human, Mouse | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human KMT5A (Leu263-His393). | ||||||||
| Цель | Histone-lysine N-methyltransferase KMT5A, PR/SET07, SETD8, SET8, PR-Set7, Lysine N-methyltransferase 5A, PRSET7, N-lysine methyltransferase KMT5A, SET domain-containing protein 8, Lysine-specific methylase 5A, H4-K20-HMTase KMT5A, SET07, KMT5A, PR/SET domain-containing protein 07 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q9NQR1 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | N-lysine methyltransferase KMT5A is a ~42 kDa protein. Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. 1. Nishioka, K. et al. (2002) Molecular cell 9, 1201-13. PMID: 12086618 2. Fang, J. et al. (2002) Current biology : CB 12, 1086-99. PMID: 12121615 3. Yin, Y. et al. (2005) The Journal of biological chemistry 280, 30025-31. PMID: 15964846 4. Shi, X. et al. (2007) Molecular cell 27, 636-46. PMID: 17707234 5. Saredi, G. et al. (2016) Nature 534, 714-718. PMID: 27338793 6. Julien, E. et al. (2004) Molecular cell 14, 713-25. PMID: 15200950 7. Xiao, B. et al. (2005) Genes & development 19, 1444-54. PMID: 15933069 8. Couture, JF. et al. (2005) Genes & development 19, 1455-65. PMID: 15933070 | ||||||||
| Примечание | For research use only. |
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