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| カタログ番号 | HP399013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA, IF, IP, IP-MS | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG1 | ||||
| クローンID | SAA0209 | ||||
| ターゲット | Lethal(3)malignant brain tumor-like protein 3, H-l(3)mbt-like protein 3, KIAA1798, L3MBTL3, L3mbt-like 3, MBT-1, L(3)mbt-like protein 3, MBT1 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q96JM7 | ||||
| RRID | Anti-Human L3MBTL3 IP Antibody (SAA0209) (abinScience Cat# HP399013, RRID:AB_3729743) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) is a ~88 kDa protein. Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression. It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation. Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins. Required for normal maturation of myeloid progenitor cells. 1. Xu, T. et al. (2017) The EMBO journal 36, 3232-3249. PMID: 29030483 2. Leng, F. et al. (2018) Nature communications 9, 1641. PMID: 29691401 3. Zhang, C. et al. (2019) The Journal of biological chemistry 294, 476-489. PMID: 30442713 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human L3MBTL3 IP Antibody (SAA0209)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
