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| カタログ番号 | HT273014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human LAMTOR5/HBXIP Polyclonal Antibody (HT273014) is a rabbit polyclonal antibody detecting LAMTOR5. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human LAMTOR5/HBXIP (Met1-Ser91). | ||||||||
| ターゲット | HBV X-interacting protein, HBX-interacting protein, HBXIP, Hepatitis B virus X-interacting protein, LAMTOR5, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5, Ragulator complex protein LAMTOR5, XIP | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O43504 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Ragulator complex protein LAMTOR5 (HBXIP) is a ~9 kDa protein. As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. 1. Bar-Peled, L. et al. (2012) Cell 150, 1196-208. PMID: 22980980 2. Yonehara, R. et al. (2017) Nature communications 8, 1625. PMID: 29158492 3. Shen, K. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 9545-9550. PMID: 30181260 4. de Araujo, MEG. et al. (2017) Science (New York, N.Y.) 358, 377-381. PMID: 28935770 5. Su, MY. et al. (2017) Molecular cell 68, 835-846.e3. PMID: 29107538 | ||||||||
| 注意事項 | For research use only |
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