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| カタログ番号 | HV606013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1616 | ||||
| ターゲット | PRSC1, Legumain, Asparaginyl endopeptidase, LGMN, Protease, cysteine 1 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q99538 | ||||
| RRID | Anti-Human LGMN/Legumain Antibody (SAA1616) (abinScience Cat# HV606013, RRID:AB_3727377) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Legumain (LGMN) is a ~49 kDa protein. Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol. Required for normal lysosomal protein degradation in renal proximal tubules. 1. Dall, E. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 10940-5. PMID: 23776206 2. Manoury, B. et al. (1998) Nature 396, 695-9. PMID: 9872320 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human LGMN/Legumain Antibody (SAA1616)
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