

| Каталожный номер | HW771014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human LIMK2 (Asp330-Pro638). | ||||||||
| Цель | LIM domain kinase 2, LIMK-2, LIMK2 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P53671 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | LIM domain kinase 2 (LIMK2) is a ~72 kDa protein. Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP. Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1. 1. Maekawa, M. et al. (1999) Science (New York, N.Y.) 285, 895-8. PMID: 10436159 2. Sumi, T. et al. (2001) The Journal of biological chemistry 276, 670-6. PMID: 11018042 3. Heng, YW. et al. (2012) Journal of cell science 125, 1579-90. PMID: 22328514 4. Okano, I. et al. (1995) The Journal of biological chemistry 270, 31321-30. PMID: 8537403 5. Kim, J. et al. (2015) Nature communications 6, 6781. PMID: 25849865 | ||||||||
| Примечание | For research use only. |
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