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| カタログ番号 | HP172014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human LIN28A Polyclonal Antibody (HP172014) is a rabbit polyclonal antibody detecting LIN28A in ELISA, IHC, WB. Suitable for Human, Mouse, and Chicken.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human LIN28A (Gln36-Gly111). | ||||||||
| ターゲット | CSDD1, Zinc finger CCHC domain-containing protein 1, LIN28, LIN28A, Lin-28A, Protein lin-28 homolog A, ZCCHC1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9H9Z2 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Protein lin-28 homolog A (LIN28A) is a ~22 kDa protein. RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (Probable). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. 1. Jin, J. et al. (2011) Nucleic acids research 39, 3724-34. PMID: 21247876 2. Heo, I. et al. (2008) Molecular cell 32, 276-84. PMID: 18951094 3. Heo, I. et al. (2009) Cell 138, 696-708. PMID: 19703396 4. Piskounova, E. et al. (2011) Cell 147, 1066-79. PMID: 22118463 5. Thornton, JE. et al. (2012) RNA (New York, N.Y.) 18, 1875-85. PMID: 22898984 | ||||||||
| 注意事項 | For research use only. |
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