

| Каталожный номер | HP172014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human LIN28A Polyclonal Antibody (HP172014) is a rabbit polyclonal antibody detecting LIN28A in ELISA, IHC, WB. Suitable for Human, Mouse, and Chicken.
Highlights
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| Реактивность видов | Human, Mouse | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human LIN28A (Gln36-Gly111). | ||||||||
| Цель | CSDD1, Zinc finger CCHC domain-containing protein 1, LIN28, LIN28A, Lin-28A, Protein lin-28 homolog A, ZCCHC1 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q9H9Z2 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Protein lin-28 homolog A (LIN28A) is a ~22 kDa protein. RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (Probable). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. 1. Jin, J. et al. (2011) Nucleic acids research 39, 3724-34. PMID: 21247876 2. Heo, I. et al. (2008) Molecular cell 32, 276-84. PMID: 18951094 3. Heo, I. et al. (2009) Cell 138, 696-708. PMID: 19703396 4. Piskounova, E. et al. (2011) Cell 147, 1066-79. PMID: 22118463 5. Thornton, JE. et al. (2012) RNA (New York, N.Y.) 18, 1875-85. PMID: 22898984 | ||||||||
| Примечание | For research use only. |
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