Anti-Human LIN28B Polyclonal Antibody (HC186014)

Name: Anti-Human LIN28B Polyclonal Antibody
Brand: abinScience
SKU: HC186014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

Nombre :

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SDS

Aperçu

Numéro de catalogue

HC186014

Description

Anti-Human LIN28B Polyclonal Antibody (HC186014) is a rabbit polyclonal antibody detecting LIN28B. Suitable for Mouse and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human LIN28B (Gln26-Gly101).

Cible

CSDD2, LIN28B, Lin-28B, Protein lin-28 homolog B

Niveau d'endotoxines

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Numéro d'accès

Q6ZN17

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Contexte

Protein lin-28 homolog B (LIN28B) is a ~27 kDa protein. Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA. Does not act on pri-miR21. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation.

1. Piskounova, E. et al. (2011) Cell 147, 1066-79. PMID: 22118463

2. Heo, I. et al. (2009) Cell 138, 696-708. PMID: 19703396

Note

For research use only

Images

Reférences

Fiche technique

Anti-Human LIN28B Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human LIN28B Polyclonal Antibody (HC186014)

Aperçu

Images

Reférences

Fiche technique

SDS