Anti-Human LMNA Polyclonal Antibody (HA509014)

Name: Anti-Human LMNA Polyclonal Antibody
Brand: abinScience
SKU: HA509014
Price: 96 USD
Availability: InStock

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20ug
50ug
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Número de catálogo

HA509014

Descripción

Anti-Human LMNA Polyclonal Antibody (HA509014) is a rabbit polyclonal antibody detecting LMNA in ELISA, IHC, WB. Suitable for Rattus norvegicus, Mus musculus, Human, Sus scrofa, and Gallus gallus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human LMNA (Thr27-Ile229).

Objetivo

LMNA

Purificación

Purified by antigen affinity column.

Número de acceso

P02545

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Nombres alternativos

Prelamin-A/C, Lamin-A/C, 70 kDa lamin, Renal carcinoma antigen NY-REN-32, LMNA, LMN1

Fondo

Prelamin-A/C (LMNA) is a ~74 kDa protein. Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties. The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively. Lamin A and C are present in equal amounts in the lamina of mammals.

1. Bonne, G. et al. (1999) Nature genetics 21, 285-8. PMID: 10080180

2. Fatkin, D. et al. (1999) The New England journal of medicine 341, 1715-24. PMID: 10580070

3. Cao, H. et al. (2000) Human molecular genetics 9, 109-12. PMID: 10587585

4. Muchir, A. et al. (2000) Human molecular genetics 9, 1453-9. PMID: 10814726

5. De Sandre-Giovannoli, A. et al. (2002) American journal of human genetics 70, 726-36. PMID: 11799477

6. Novelli, G. et al. (2002) American journal of human genetics 71, 426-31. PMID: 12075506

7. Chen, L. et al. (2003) Lancet (London, England) 362, 440-5. PMID: 12927431

8. Navarro, CL. et al. (2004) Human molecular genetics 13, 2493-503. PMID: 15317753

9. Quijano-Roy, S. et al. (2008) Annals of neurology 64, 177-86. PMID: 18551513

10. Renou, L. et al. (2008) Journal of medical genetics 45, 666-71. PMID: 18611980

Nota

For research use only.

Imágenes

Western blot

Western blot analysis was performed using anti-LMNA polyclonal antibody at 1ug/mL on various samples.
Lane 1: A549 cell lysate
Lane 2: Hela cell lysate
Lane 3: A375 cell lysate

Referencias

Datasheet

Anti-Human LMNA Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Human LMNA Polyclonal Antibody (HA509014)

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Referencias

Datasheet

SDS