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| カタログ番号 | HA509014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human LMNA Polyclonal Antibody (HA509014) is a rabbit polyclonal antibody detecting LMNA in ELISA, IHC, WB. Suitable for Rattus norvegicus, Mus musculus, Human, Sus scrofa, and Gallus gallus.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human LMNA (Thr27-Ile229). | ||||||||
| ターゲット | LMNA | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P02545 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 別名 | Prelamin-A/C, Lamin-A/C, 70 kDa lamin, Renal carcinoma antigen NY-REN-32, LMNA, LMN1 | ||||||||
| 背景 | Prelamin-A/C (LMNA) is a ~74 kDa protein. Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties. The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively. Lamin A and C are present in equal amounts in the lamina of mammals. 1. Bonne, G. et al. (1999) Nature genetics 21, 285-8. PMID: 10080180 2. Fatkin, D. et al. (1999) The New England journal of medicine 341, 1715-24. PMID: 10580070 3. Cao, H. et al. (2000) Human molecular genetics 9, 109-12. PMID: 10587585 4. Muchir, A. et al. (2000) Human molecular genetics 9, 1453-9. PMID: 10814726 5. De Sandre-Giovannoli, A. et al. (2002) American journal of human genetics 70, 726-36. PMID: 11799477 6. Novelli, G. et al. (2002) American journal of human genetics 71, 426-31. PMID: 12075506 7. Chen, L. et al. (2003) Lancet (London, England) 362, 440-5. PMID: 12927431 8. Navarro, CL. et al. (2004) Human molecular genetics 13, 2493-503. PMID: 15317753 9. Quijano-Roy, S. et al. (2008) Annals of neurology 64, 177-86. PMID: 18551513 10. Renou, L. et al. (2008) Journal of medical genetics 45, 666-71. PMID: 18611980 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-LMNA polyclonal antibody at 1ug/mL on various samples.
Lane 1: A549 cell lysate
Lane 2: Hela cell lysate
Lane 3: A375 cell lysate
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