Anti-Human LONP1 Polyclonal Antibody (HA513014)

Name: Anti-Human LONP1 Polyclonal Antibody
Brand: abinScience
SKU: HA513014
Price: 96 USD
Availability: InStock

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Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HA513014

Descripción

Anti-Human LONP1 Polyclonal Antibody (HA513014) is a rabbit polyclonal antibody detecting LONP1 in ELISA, IHC, WB. Suitable for Rattus norvegicus, Bovine, Mus musculus, and Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human LONP1 (Phe421-Phe947).

Objetivo

LONP1

Purificación

Purified by antigen affinity column.

Número de acceso

P36776

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Nombres alternativos

Lon protease homolog, mitochondrial, 3.4.21.53, LONHs, Lon protease-like protein, LONP, Mitochondrial ATP-dependent protease Lon, Serine protease 15, LONP1, PRSS15

Fondo

Lon protease homolog, mitochondrial (LONP1) is a ~106 kDa protein. ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, DELE1, helicase Twinkle (TWNK) and the large ribosomal subunit protein MRPL32/bL32m. MRPL32/bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome.

1. Bota, DA. et al. (2002) Nature cell biology 4, 674-80. PMID: 12198491

2. Ondrovicová, G. et al. (2005) The Journal of biological chemistry 280, 25103-10. PMID: 15870080

3. Granot, Z. et al. (2007) Molecular endocrinology (Baltimore, Md.) 21, 2164-77. PMID: 17579211

4. Sekine, Y. et al. (2023) Molecular cell 83, 2059-2076.e6. PMID: 37327776

5. Wang, N. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 11247-51. PMID: 8248235

6. Kunová, N. et al. (2017) Scientific reports 7, 631. PMID: 28377575

Nota

For research use only.

Imágenes

Western blot

Western blot analysis was performed using anti-LONP1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Hela cell lysate
Lane 2: HepG2 cell lysate
Lane 3: Mouse heart lysate

Referencias

Datasheet

Anti-Human LONP1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo