Anti-Human LONP1 Polyclonal Antibody (HA513014)

Name: Anti-Human LONP1 Polyclonal Antibody
Brand: abinScience
SKU: HA513014
Price: 96 USD
Availability: InStock

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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HA513014

Description

Anti-Human LONP1 Polyclonal Antibody (HA513014) is a rabbit polyclonal antibody detecting LONP1 in ELISA, IHC, WB. Suitable for Rattus norvegicus, Bovine, Mus musculus, and Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human LONP1 (Phe421-Phe947).

Cible

LONP1

Purification

Purified by antigen affinity column.

Numéro d'accès

P36776

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Noms alternatifs

Lon protease homolog, mitochondrial, 3.4.21.53, LONHs, Lon protease-like protein, LONP, Mitochondrial ATP-dependent protease Lon, Serine protease 15, LONP1, PRSS15

Contexte

Lon protease homolog, mitochondrial (LONP1) is a ~106 kDa protein. ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, DELE1, helicase Twinkle (TWNK) and the large ribosomal subunit protein MRPL32/bL32m. MRPL32/bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome.

1. Bota, DA. et al. (2002) Nature cell biology 4, 674-80. PMID: 12198491

2. Ondrovicová, G. et al. (2005) The Journal of biological chemistry 280, 25103-10. PMID: 15870080

3. Granot, Z. et al. (2007) Molecular endocrinology (Baltimore, Md.) 21, 2164-77. PMID: 17579211

4. Sekine, Y. et al. (2023) Molecular cell 83, 2059-2076.e6. PMID: 37327776

5. Wang, N. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 11247-51. PMID: 8248235

6. Kunová, N. et al. (2017) Scientific reports 7, 631. PMID: 28377575

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-LONP1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Hela cell lysate
Lane 2: HepG2 cell lysate
Lane 3: Mouse heart lysate

Reférences

Fiche technique

Anti-Human LONP1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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