中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HA513014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human LONP1 Polyclonal Antibody (HA513014) is a rabbit polyclonal antibody detecting LONP1 in ELISA, IHC, WB. Suitable for Rattus norvegicus, Bovine, Mus musculus, and Human.
Highlights
|
||||||||
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human LONP1 (Phe421-Phe947). | ||||||||
| ターゲット | LONP1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P36776 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 別名 | Lon protease homolog, mitochondrial, 3.4.21.53, LONHs, Lon protease-like protein, LONP, Mitochondrial ATP-dependent protease Lon, Serine protease 15, LONP1, PRSS15 | ||||||||
| 背景 | Lon protease homolog, mitochondrial (LONP1) is a ~106 kDa protein. ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, DELE1, helicase Twinkle (TWNK) and the large ribosomal subunit protein MRPL32/bL32m. MRPL32/bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. 1. Bota, DA. et al. (2002) Nature cell biology 4, 674-80. PMID: 12198491 2. Ondrovicová, G. et al. (2005) The Journal of biological chemistry 280, 25103-10. PMID: 15870080 3. Granot, Z. et al. (2007) Molecular endocrinology (Baltimore, Md.) 21, 2164-77. PMID: 17579211 4. Sekine, Y. et al. (2023) Molecular cell 83, 2059-2076.e6. PMID: 37327776 5. Wang, N. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 11247-51. PMID: 8248235 6. Kunová, N. et al. (2017) Scientific reports 7, 631. PMID: 28377575 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-LONP1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Hela cell lysate
Lane 2: HepG2 cell lysate
Lane 3: Mouse heart lysate
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
