Anti-Human LONP1 Polyclonal Antibody (HA513014)

Name: Anti-Human LONP1 Polyclonal Antibody
Brand: abinScience
SKU: HA513014
Price: 96 USD
Availability: InStock

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Обзор

Каталожный номер

HA513014

Описание

Anti-Human LONP1 Polyclonal Antibody (HA513014) is a rabbit polyclonal antibody detecting LONP1 in ELISA, IHC, WB. Suitable for Rattus norvegicus, Bovine, Mus musculus, and Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human LONP1 (Phe421-Phe947).

Цель

LONP1

Очистка

Purified by antigen affinity column.

Номер доступа

P36776

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Альтернативные названия

Lon protease homolog, mitochondrial, 3.4.21.53, LONHs, Lon protease-like protein, LONP, Mitochondrial ATP-dependent protease Lon, Serine protease 15, LONP1, PRSS15

Фон

Lon protease homolog, mitochondrial (LONP1) is a ~106 kDa protein. ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, DELE1, helicase Twinkle (TWNK) and the large ribosomal subunit protein MRPL32/bL32m. MRPL32/bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome.

1. Bota, DA. et al. (2002) Nature cell biology 4, 674-80. PMID: 12198491

2. Ondrovicová, G. et al. (2005) The Journal of biological chemistry 280, 25103-10. PMID: 15870080

3. Granot, Z. et al. (2007) Molecular endocrinology (Baltimore, Md.) 21, 2164-77. PMID: 17579211

4. Sekine, Y. et al. (2023) Molecular cell 83, 2059-2076.e6. PMID: 37327776

5. Wang, N. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 11247-51. PMID: 8248235

6. Kunová, N. et al. (2017) Scientific reports 7, 631. PMID: 28377575

Примечание

For research use only.

Изображения

Western blot

Western blot analysis was performed using anti-LONP1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Hela cell lysate
Lane 2: HepG2 cell lysate
Lane 3: Mouse heart lysate

Ссылки

Даташит

Anti-Human LONP1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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