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| カタログ番号 | HC198014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human LRPPRC Polyclonal Antibody (HC198014) is a rabbit polyclonal antibody detecting LRPPRC. Suitable for Human.
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human LRPPRC (Thr385-Asp725). | ||||||||
| ターゲット | 130 kDa leucine-rich protein, GP130, LRP 130, LRP130, LRPPRC, Leucine-rich PPR motif-containing protein, mitochondrial | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P42704 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC) is a ~157 kDa protein. May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex. Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm. May bind mature mRNA in the nucleus outer membrane. 1. Topisirovic, I. et al. (2009) The EMBO journal 28, 1087-98. PMID: 19262567 2. Volpon, L. et al. (2017) RNA (New York, N.Y.) 23, 927-937. PMID: 28325843 3. Zou, J. et al. (2013) The Biochemical journal 454, 447-57. PMID: 23822101 | ||||||||
| 注意事項 | For research use only |
Western blot analysis was performed using anti-LRPPRC polyclonal antibody at 1ug/mL on various samples.
Lane 1: HepG2 cell lysate
Lane 2: SH-SY5Y cell lysate
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