

| Numéro de catalogue | HP210014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human LRR1 Polyclonal Antibody (HP210014) is a rabbit polyclonal antibody detecting LRR1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human LRR1 (Lys135-Gly303). | ||||||||
| Cible | 4-1BBlrr, LRR1, PPIL5, Peptidylprolyl isomerase-like 5, 4-1BB-mediated-signaling molecule, LRR-repeat protein 1, LRR-1, Leucine-rich repeat protein 1 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q96L50 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Leucine-rich repeat protein 1 (LRR1) is a ~46 kDa protein. Substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase. May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. 1. Kamura, T. et al. (2004) Genes & development 18, 3055-65. PMID: 15601820 2. Jang, LK. et al. (2001) Molecules and cells 12, 304-12. PMID: 11804328 | ||||||||
| Note | For research use only. |
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