

| Каталожный номер | HD329014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human LRRC8E Polyclonal Antibody (HD329014) is a rabbit polyclonal antibody detecting LRRC8E. Suitable for Human.
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human LRRC8E (Leu411-Glu796). | ||||||||
| Цель | LRRC8E, Leucine-rich repeat-containing protein 8E, Volume-regulated anion channel subunit LRRC8E | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q6NSJ5 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Фон | Volume-regulated anion channel subunit LRRC8E is a ~90 kDa protein. Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Mediates efflux of amino acids, such as aspartate, in response to osmotic stress. The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. 1. Voss, FK. et al. (2014) Science (New York, N.Y.) 344, 634-8. PMID: 24790029 2. Syeda, R. et al. (2016) Cell 164, 499-511. PMID: 26824658 3. Lutter, D. et al. (2017) Journal of cell science 130, 1122-1133. PMID: 28193731 4. Lahey, LJ. et al. (2020) Molecular cell 80, 578-591.e5. PMID: 33171122 | ||||||||
| Примечание | For research use only |
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