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| カタログ番号 | HY412014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human LTA4H Polyclonal Antibody (HY412014) is a rabbit polyclonal antibody detecting LTA4H in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human LTA4H (Met1-Leu210). | ||||||||
| ターゲット | Leukotriene A-4 hydrolase, LTA-4 hydrolase, 3.3.2.6, Leukotriene A(4) hydrolase, Tripeptide aminopeptidase LTA4H, 3.4.11.4, LTA4H, LTA4 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P09960 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Leukotriene A-4 hydrolase (LTA4H) is a ~69 kDa protein. Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4). Can utilize LTA5 less effectively as a substrate than LTA4, and produce LTB5. Also has aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides. In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL). 1. Rudberg, PC. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 4215-20. PMID: 11917124 2. Thunnissen, MM. et al. (2002) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 16, 1648-50. PMID: 12207002 3. Rudberg, PC. et al. (2004) The Journal of biological chemistry 279, 27376-82. PMID: 15078870 4. Tholander, F. et al. (2008) Chemistry & biology 15, 920-9. PMID: 18804029 5. Odlander, B. et al. (1991) Archives of biochemistry and biophysics 287, 167-74. PMID: 1897988 6. Toh, H. et al. (1990) Biochemical and biophysical research communications 171, 216-21. PMID: 1975494 7. Haeggström, JZ. et al. (1990) Biochemical and biophysical research communications 172, 965-70. PMID: 2244921 8. Nathaniel, DJ. et al. (1985) Biochemical and biophysical research communications 131, 827-35. PMID: 2996528 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-LTA4H polyclonal antibody at 1ug/mL on various samples.
Lane 1: Hela cell lysate
Lane 2: A549 cell lysate
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